How to reference a clinical trial?

Written by
Khalil Ben Yahia
Published on
May 4, 2026

Referencing a clinical trial correctly is not just a formality. It is an essential step to ensure data transparency, study reproducibility, and scientific integrity. Whether you are a researcher, student, or healthcare professional, knowing how to cite a clinical study according to current standards helps anchor your work in a rigorous and recognized framework. In short: a good citation starts with identifying the source (registry, publication, NCT identifier), choosing the appropriate style (APA, AMA), and including key elements such as the title, authors, and type of intervention.

Accurate referencing makes it possible to:

  • Formally identify the study
  • Verify consistency between the protocol and publication
  • Avoid publication bias
  • Ensure reproducibility

How to cite a clinical trial in APA or AMA style?

The citation style depends on the publication context. Here are the two most common formats:

APA style (American Psychological Association)

Name, P. (Year). Title of the trial. ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCTXXXXXXXX

AMA style (American Medical Association)

Name P. Study title. ClinicalTrials.gov. NCT Identifier: NCTXXXXXXXX. Updated [date]. Accessed [date].

In both cases, the NCT identifier, the unique number assigned by the ClinicalTrials.gov registry, is essential. It allows the trial to be retrieved at any time and its data to be verified in real time.

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Where can reliable information on clinical trials be found?

Several official registries provide access to structured and verified information on ongoing or completed clinical trials:

  • ClinicalTrials.gov: the reference registry, managed by the NIH, which lists thousands of studies worldwide.
  • EU Clinical Trials Register: dedicated to clinical trials conducted within the European Union.
  • ISRCTN Registry: an international registry recognized by the WHO, used in particular for public health studies.
  • WHO ICTRP: the international platform of the World Health Organization, which aggregates data from several national registries.

These platforms provide the following information for each trial: title, objectives, type of intervention, expected number of participants, and inclusion criteria.

What are the best practices for registering a clinical trial?

Prospective registration is now a regulatory and editorial requirement.

1. Register before enrolling the first patient

Required by most scientific journals and regulatory authorities.

2. Enter the key structuring elements

  • Primary objective
  • Primary endpoint
  • Sample size
  • Intervention plan
  • Target population

3.Ensure document consistency

The registry must be aligned with:

  • The protocol
  • The statistical analysis plan
  • The final publication

Inconsistencies are frequently detected during peer review.

4. Update the status

  • Recruiting
  • Active, not recruiting
  • Completed
  • Terminated

Khalil Ben Yahia
Clinical Trials Expert

With over 10 years of experience working in CROs, Khalil brings deep expertise in clinical trials and a clear understanding of the daily challenges faced by research professionals. His insights are grounded in real-world operations, making his perspective both practical and strategic.

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